New Topics In Vitamin D Research

Autor: Veronica D. Stolzt
Publisher: Nova Publishers
ISBN: 9781600210013
File Size: 21,28 MB
Format: PDF, Kindle
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Vitamin D is a fat-soluble steroid hormone precursor that contributes to the maintenance of normal levels of calcium and phosphorus in the bloodstream. Strictly speaking, it is not a vitamin since human skin can manufacture it, but it is referred to as one for historical reasons. It is often known as calciferol. The major biologic function of vitamin D is to maintain normal blood levels of calcium and phosphorus. Vitamin D aids in the absorption of calcium, helping to form and maintain strong bones. It promotes bone mineralisation in concert with a number of other vitamins, minerals and hormones. Without vitamin D, bones can become thin, brittle, soft or misshapen. Vitamin D prevents rickets in children and osteomalacia in adults - skeletal diseases that result in defects that weaken bones. This book gathers international research on the leading-edge of the scientific front.

New Topics In Cancer Research

Autor: Fredrick G. Drabell
Publisher: Nova Publishers
ISBN: 9781600211553
File Size: 44,27 MB
Format: PDF
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Cancer is a group of different diseases (more than 100) characterised by uncontrolled growth and spread of abnormal cells. Cancer can arise in many sites and behave differently depending on its organ of origin. If a cancer spreads (metastasizes), the new tumour bears the same name as the original (primary) tumour. Significant progress has been made in recent years in the battle against cancer and in understanding its underlying biological mechanisms. This research progress has resulted in many experimental treatments and cures which establish hope for wide-spread cures. This book brings together important research from around the world in this frontal field.

New Topics In Tuberculosis Research

Autor: Donald D. Spiegelburg
Publisher: Nova Publishers
ISBN: 9781600211591
File Size: 44,60 MB
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Tuberculosis, the disease that the World Health Organization has recently declared a global emergency, was supposedly defeated by antibiotics half a century ago. It has returned in a highly contagious and fatal new form that cannot be treated with conventional drugs. Multidrug-resistant TB (MDR-TB), could cause some 10 million deaths over the next decade and is thriving in the overcrowded prisons of the former Soviet Union. The virtual collapse of the world's borders means that refugees, tourists, immigrants, business travellers, and others can spread the TB bacillus very efficiently. London, for example, has experienced a 100 per cent increase in reported cases in the past 10 years. This book covers all aspects of the disease: epidemiology, microbiology, diagnosis, treatment, control and prevention. Leading research is presented from centres around the world.

Vitamin D Analogs In Cancer Prevention And Therapy

Autor: J. Reichrath
Publisher: Springer Science & Business Media
ISBN: 3642555802
File Size: 57,58 MB
Format: PDF
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A comprehensive, highly readable overview of the topics discussed at the First International Symposium on "Vitamin D Analogs in Cancer Prevention and Therapy" held in Homburg/Saar, Germany in May 2002. Leading researchers discuss our present knowledge of the vitamin D system in cancer. Topics range from the newest findings in molecular biology, epidemiology, synthesis and metabolism of vitamin D to new concepts for the use of vitamin D analogs in cancer prophylaxis and treatment. The book provides essential up-to-date information for every researcher or clinician interested in the biology of vitamin D or cancer.

Vitamin D

Autor: David Feldman
Publisher: Academic Press
ISBN: 012809964X
File Size: 35,92 MB
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Vitamin D: Volume 2: Health, Disease and Therapeutics, Fourth Edition, authoritatively covers the evidence for new roles for vitamin D, ranging from cardiovascular disease, to cancer, diabetes, inflammatory bowel disease, multiple sclerosis and renal disease. This collection represents a who’s who of vitamin D research and the coverage is appropriately broad, drawing in internal medicine, orthopedics, oncology and immunology. Clinical researchers will gain a strong understanding of the molecular basis for a particular area of focus. Offers a comprehensive reference, ranging from basic bone biology, to biochemistry, to the clinical diagnostic and management implications of vitamin D Saves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of Vitamin D, as opposed to searching through thousands of journal articles Chapter authors include the most prominent and well-published names in the field Targets chemistry, metabolism and circulation, mechanisms of action, mineral and bone homeostasis and vitamin D deficiency Presents a clinical focus on disorders, analogs, cancer, immunity, inflammation, disease and therapeutic applications

Genome Wide View On The Physiology Of Vitamin D

Autor: Carsten Carlberg
Publisher: Frontiers E-books
ISBN: 2889193497
File Size: 32,55 MB
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The main physiological actions of the biologically most active metabolite of vitamin D, 1a,25-dihydroxyvitamin D3(1a,25(OH)2D3), are calcium and phosphorus uptake and transport and thereby controlling bone formation. Other emergent areas of 1a,25(OH)2D3 action are in the control of immune functions, cellular growth and differentiation. This fits both with the widespread expression of the VDR and the above described consequences of vitamin D deficiency. Transcriptome-wide analysis indicated that per cell type between 200 and 600 genes are primary targets of vitamin D. Since most of these genes respond to vitamin D in a cell-specific fashion, the total number of vitamin D targets in the human genome is far higher than 1,000. This is supported by the genome-wide view on VDR binding sites in human lymphocytes, monocytes, colon and hepatic cells. All genomic actions of 1a,25(OH)2D3 are mediated by the transcription factor vitamin D receptor (VDR) that has been the subject of intense study since the 1980’s. Thus, vitamin D signaling primarily implies the molecular actions of the VDR. In this research topic, we present in 15 chapters different perspectives on the action of vitamin D and its receptor, such as the impact of the genomewide distribution of VDR binding loci, ii) the transcriptome- and proteome-wide effects of vitamin D, iii) the role of vitamin D in health, iv) tissue-specific functions of vitamin D and v) the involvement of vitamin D in different diseases, such as infections, autoimmune diseases, diabetes and different types of cancer.

Vitamin D

Autor: Adrian F. Gombart
Publisher: CRC Press
ISBN: 1439850216
File Size: 61,74 MB
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Vitamin D insufficiency/deficiency is a worldwide, public health problem in both developed and developing countries. Rickets among infants has reemerged. Low levels of vitamin D are associated with increased risk and mortality from cancer. At the same time, the beneficial effects of vitamin D on a host of conditions have recently been discovered. Focusing on areas not extensively covered in other comparable books, Vitamin D: Oxidative Stress, Immunity, and Aging highlights the most recent research findings on the impact of this nutrient in oxidative stress, immunity, and aging. A state-of-the-art compilation of essential information, this book explores: Vitamin D and its genomic and nongenomic effects, the role of therapeutic analogs in treating disease, and the production of vitamin D by the body The role vitamin D plays in modulating oxidative stress—with emphasis on cancer, stress-mediated diseases, photo-protection of the skin, and energy metabolism Beneficial effects of vitamin D in regulating the immune response and its importance in protecting against autoimmune, infectious, and inflammatory diseases The role vitamin D plays in the regulation of the aging process—including aspects of oxidative stress, senescence, and mortality, as well as its role in protection against cardiovascular disease and nervous system disorders This book represents an important contribution toward understanding the mechanisms by which vitamin D promotes health, increasing awareness of the importance that vitamin D plays during development, at birth, and throughout the aging process. It is a valuable reference for researchers in academia, nutrition, medicine, and industry.

Nutritional Influences On Bone Health

Autor: Peter Burckhardt
Publisher: Springer Science & Business Media
ISBN: 1447127692
File Size: 17,67 MB
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Nutritional Influences on Bone Health presents a collection of papers from the 8th International Symposium on Nutritional Aspects of Osteoporosis, the primary forum for and only regular meeting exclusively devoted to the topic of nutritional influences on bone health. The outcome is a fusion of the most current and up-to-date research in this area. Key themes include the permeation of the Western diet across the globe, calcium, vitamin D and acid-base balance. Written by authorities on the impact of nutrition on bone health, Nutritional Influences on Bone Health brings the reader the emerging trends, new messages and the latest scientific data in the field, to inform future research and clinical practice. This comprehensive, well researched volume is an essential reference for professionals in the field of bone health and nutrition.

Vitamin D

Autor: Cobus Meer
Publisher: Nova Science Pub Incorporated
ISBN: 9781628088151
File Size: 63,85 MB
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In this book, the authors present topical research in the study of the daily requirements, dietary sources and symptoms of deficiency of Vitamin D. Topics discussed in this compilation include the history and modern controversies of vitamin D fortification and supplementation; vitamin D in the immune system and role of its deficiency in rheumatic diseases; genetic and epigenetic changes of vitamin D related genes in cancer; advances and pitfalls in the measurement of vitamin D; vitamin D's implications for muscle function and physical performance; evidence for positive effects of vitamin D supplementation on disease conditions beyond bone health in adults; hypovitaminosis D and osteopenia/osteoporosis in a haemophilia population; vitamin D and aging in the elderly; and hypovitaminosis D and cardiovascular disease.

Papulosquamous Skin Diseases Advances In Research And Treatment 2011 Edition

Autor:
Publisher: ScholarlyEditions
ISBN: 1464930694
File Size: 48,19 MB
Format: PDF, Mobi
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Papulosquamous Skin Diseases: Advances in Research and Treatment: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Papulosquamous Skin Diseases. The editors have built Papulosquamous Skin Diseases: Advances in Research and Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Papulosquamous Skin Diseases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Papulosquamous Skin Diseases: Advances in Research and Treatment: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.