The Molecular Basis Of Sex And Differentiation

Autor: Milton H. Saier
Publisher: Springer Science & Business Media
ISBN: 1461252601
File Size: 13,52 MB
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Man's mind stretched to a new idea never goes back to its original dimensions Oliver Wendell Holmes Our current understanding of sex and biological differentiation results from the application of three principal experimental approaches to these subjects: those of the physiologist, the biochemist, and the geneticist. These three approaches are illustrated by the materials presented in the chapters of this volume. Chapters 1-5 emphasize conceptualization of developmental processes, describing systems principally from the standpoint of the physiologist. Structures and functions are defined with only occasional reference to specific molecular details. Chapters 6- 10 present the views of the biochemist, attempting to describe functions influ encing or regulating cellular behavior at the molecular level. And Chapters 11- 14 illustrate the approaches of the modem-day geneticist in his attempts to gain a detailed understanding of processes controlling gene expression. While it is possible to delineate these three major sections, each emphasizing a distinct experimental approach, it must be realized that the yield of knowledge increases exponentially with the number of experimental approaches available to the investigator. Information resulting from the application of each of these approaches must converge to give the same answers for anyone biological phenomenon in anyone experimental system. Further, if we can learn of details regarding a particular process by applying different experimental approaches, our postulates concerning the underlying molecular mechanisms are likely to be more accurate. But biological systems are not unrelated.

Genetics Of Sex Differentiation

Autor: Ursula Mittwoch
Publisher: Elsevier
ISBN: 0323158501
File Size: 26,31 MB
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Genetics of Sex Differentiation intends to help readers understand the genetic basis of sex differentiation. The book focuses on explaining how the sex chromosomes affect the process of sex differentiation by influencing the rates at which cells divide. The book is composed of seven chapters. It provides overviews of classical genetics and structure of cells. It also explains the chromosomal basis of sex determination and sex determination using Drosophila. Polygenetics and continuous and quasicontinuous variations are also discussed. The book also discusses sex factors, determination, and disorders. Moreover, it explains the heterochromatin, embryological basis of sex differentiation, and triploidy and autosomal effects. In addition, it discusses the relationship of genes, chromosomes, growth, and sex. The book is an excellent ""bedside book"" for students in biology, specifically in genetics and developmental biology. Lecturers and professionals in biology and genetics will also find this book invaluable for their practice.

Molecular Genetics Of Sex Determination

Autor: Stephen S. Wachtel
Publisher: Academic Press
ISBN: 1483295583
File Size: 22,46 MB
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In this era of accelerated discovery and prolific output, Molecular Genetics of Sex Determination keeps readers abreast of this fields fast-moving biology. Its chapters were completed by experts in eacharea only months before publication. The text is organized into two parts. First, it reviews the basic biology of sex determination and summarizes ground-breaking work in mouse, marsupial, and Drosophila systems. Second, it covers current human genetics, clinical studies, and the syndromes of abnormal sex differentiation. With chapters by preeminent reproductive biologists, this is a capital work. Ohno's law is described by Ohno; the Lyon hypothesis, by Lyon; Sinclair tells how he cloned the testis-determining gene; and so on. Molecular Genetics of Sex Determination is authoritative, comprehensive, and current. It is prime reading for geneticists, developmental biologists, graduate students in these and related fields, clinical researchers, physicians, and medical students. Reviews the genetics of sex determination in 19 up-to-date chapters Features research on sex chromosomes and sex-determining genes Includes abnormalities of sex determination and clinical genetics Written by scientists who pioneered work in this field

Sex Determination Differentiation And Intersexuality In Placental Mammals

Autor: R. H. F. Hunter
Publisher: Cambridge University Press
ISBN: 9780521462181
File Size: 76,81 MB
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How do males become male and females become female? And what are the consequences if the decision is not incisive? Drawing upon interests in animal genetics and molecular biology, the author endeavours to answer these difficult yet fascinating questions. Originally published in 1995, this book describes the genetic determination of sex and examines how sexual organs are differentiated. Using examples of intersexuality, chimaeras and asymmetries, the book describes the underlying molecular basis of sex determination and sexual differentiation, and focuses on the critical role of the rate of embryonic development in these vital processes. Male precocity is a recurrent theme, as is the involvement of Sertoli cells and their secretion of anti-Mllerian hormone. An invaluable book for reproductive physiologists, geneticists and developmental biologists whose interests may extend from animal science through veterinary medicine to human clinical medicine.

Hormonal And Genetic Basis Of Sexual Differentiation Disorders And Hot Topics In Endocrinology Proceedings Of The 2nd World Conference

Autor: Maria I. New
Publisher: Springer Science & Business Media
ISBN: 9781441980021
File Size: 39,37 MB
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Proceedings of the 2nd World Conference – Hormonal and Genetic Basis of Sexual Differentiation Disorders and Hot Topics in Endocrinology. The meeting took place at The Eden Roc Hotel in Miami Beach, Florida, 1/15/10 – 1/17-10. Endocrinology and more specifically, the area of sexual differentiation disorders is an evolving field of medicine. The diagnosis and treatment of Disorders of Sex Development (DSD) is multi-faceted.

Sexual Differentiation Of The Brain

Autor: Akira Matsumoto
Publisher: CRC Press
ISBN: 9781439832288
File Size: 49,38 MB
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Sexual difference in the brain has long been one of the more intriguing research areas in the field of neuroscience. This thorough and comprehensive text uncovers and explains recent neurobiological and molecular biological studies in the field of neuroscience as they relate to the mechanisms underlying sexual differentiation of the brain. Attempts have been made to clarify sex differences in the human brain using noninvasive techniques such as magnetic resonance imaging. Sexual Differentiation of the Brain thoroughly examines these techniques and findings, providing an up-to-date, comprehensive overview written by leading researchers in the field. Just a few of the topics addressed include genetic contributions to the sexual differentiation of behavior; in-vitro studies of the effects of estrogen on estrogen receptor-transfected neuroblastoma cells; and the evolution of brain mechanisms controlling sexual behavior. Other topics include sexual differentiation of neural circuitry in the hypothalamus; structural sex differences in the mammalian brain; and sexual differentiation of cognitive functions in humans. With its revealing and informative chapters, as well as provocative treatment of the subject matter, Sexual Differentiation of the Brain helps shed new light on one of the most fascinating areas of brain research.

The Genetic Basis Of Male Infertility

Autor: Ken McElreavey
Publisher: Springer Science & Business Media
ISBN: 9783540662648
File Size: 44,10 MB
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Every year there are new and exciting developments in assisted human reproduction, but how much do we really know about the underlying causes of infertility? This volume explores recent progress in the understanding of the genetics of spermatogenesis and male infertility. Topics include fundamental advances and current problems in the development and function of the testis, an outline of clinical findings in male infertility and an overview of the role of the Y chromosome in male fertility. Comprehensive critiques of posttranscriptional control during spermatogenesis, mammalian meiotic sterility, and comparative genetics of human spermatogenesis from the perspective of yeast, Drosophila and mice provide a global overview of the field.

Genetics Of Sexual Differentiation And Sexually Dimorphic Behaviors

Autor: Daisuke Yamamoto
Publisher: Elsevier
ISBN: 9780080551609
File Size: 32,71 MB
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The field of genetics is rapidly evolving and new medical breakthroughs are occuring as a result of advances in knowledge of genetics. Advances in Genetics continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. Nine chapters on the most advanced research on the differentiating behaviors among sexes More than 300 pages of articles from leading international scientists, this volume offers genetic behaviorial information related to drosophila, mice, birds, voles, and mammals Hot topics include sex differences in brain and behavior; genomic imprinting and the evolution of sex differences; gene regulation; peptide pheromone production and reception, and more